For the successful renal grafting which of the following set of antigen is not important?

a. ABO red blood cell
b. Lewis Red cell antigen
c. Sex antigen
d. MHC II antigen

Gaurab Karki Level 2 Asked on October 23, 2015 in Immunology.
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1 Answer(s)

I think its c. Sex antigen

But,
Female donor kidneys had poorer graft survival rates than male donor kidneys.
Use of cyclosporine (CsA), pretransplant transfusions, and HLA-A,B mismatches independently contributed to the poorer survival rates of female donor kidneys. A large component of the donor sex effect may have been related to CsA toxicity.
Broadly sensitized (greater than 50% PRA) recipients of first transplants had 8% lower 1-year graft survival rates when they received a female donor kidney.
Female donors between the ages of 36 and 45 years yielded significantly lower 1-year graft survival rates in recipients of both first transplants and regrafts. This may represent a special donor risk group.

Sagar Aryal Admin Answered on October 24, 2015.

you explained right.
For the successful grafting there is biases on gender, it is considered that if a female patient receive a kidney from female donor there is higher survival rate. so, sex antigen is important to consider during grafting.
The answer is not c.

on October 25, 2015.

Then I think or I am sure b. Lewis Red cell antigen is the correct answer

on October 25, 2015.

Hi . I am interested in renal transplantation and renal grafting. Can you please recommend me a good read?

on October 26, 2015.
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